The addition of 'clinically significant impairment' (American Psychiatric Association, Diagnostic and statistical manual of mental disorders, Author, 2013) to the diagnostic criteria for autism in DSM-5 attempts to establish a threshold for the condition. However, the increased prominence of the neurodiversity paradigm and social model of…

Autism is heterogeneous at many levels, including clinical symptoms and etiology. A key strategy in studying heterogeneous conditions is having large enough sample sizes to stratify into smaller groups that are more homogeneous. SPARK and Simons Searchlight are large and growing research cohorts of individuals with autism in the United States and…

The past fifteen years has seen a dramatic improvement in our understanding of hearing and hearing loss. Scientists have worked to identify dozens of genes involved in hearing loss and elucidate the complex molecular machinery responsible for hearing. At the same time, there have been rapid advances in clinical diagnostic tools including imaging…

The addition of disruptive mood dysregulation disorder (DMDD) to the fifth edition of the "Diagnostic and Statistical Manual of Mental Disorders" ("DSM-5") was a controversial decision in 2013 and one that continues to the present. Researchers have found that DMDD exhibits both poor interrater reliability and discriminant…

This paper describes a process to define a comprehensive list of exemplars for seven core Diagnostic and Statistical Manual (DSM) diagnostic criteria for autism spectrum disorder (ASD), and report on interrater reliability in applying these exemplars to determine ASD case classification. Clinicians completed an iterative process to map specific…

Although it is recognised that autism spectrum disorder (ASD) and personality disorders (PDs) have a variety of factors in common, the exact nature of the relationship between ASD and the PDs remains unclear. The overlapping symptom profiles and complexities in developmental trajectories in ASD and PDs can lead to diagnostic uncertainty and to…

Anxiety is now recognized as one of the most common co-occurring conditions in youth diagnosed with autism spectrum disorder (ASD). Despite the prevalence of this comorbid condition, accurate assessment and diagnosis of anxiety in ASD has proven difficult. This paper will address the considerable research literature on assessing anxiety in youth…

Medical students are called to acquire competence to manage disease in its dynamic evolution over time, learning to analyze how clinical conditions evolve in a patient's history and how each condition interferes with the evolution of the other coexisting conditions. In this article, the health issue network (HIN) approach is introduced as a formal…

Intervention is considered the ultimate goal of the diagnostic process. However, when diagnostic assessment is largely focused on student (mal)adjustment and when the role and perspective of the teacher is not systematically evaluated, the assessment may fail to generate useful recommendations for intervention or teacher consultation. Based on a…

Individuals living with intellectual disability can have multiple co-occurring medical conditions including associated genetic diagnoses. The number of genetic etiologies associated with ID is growing, with some quite new and rare, and others more common and associated with what is often considered a syndrome. In the context of genetic etiologies…

Western blot (WB) or immunoblot is a workhorse method. It is commonly used by biologists for study of different aspects of protein biomolecules. In addition, it has been widely used in disease diagnosis. Despite some limitations such as long time, different applications of WB have not been limited. In the present review, we have summarized…

The polymerase chain reaction (PCR) technique is one of the most potent tools in molecular biology. It is extensively used for various applications ranging from medical diagnostics to forensic science and food quality testing. This technique has facilitated to survive COVID-19 pandemic by identifying the virus-infected individuals effortlessly and…

Children with mucopolysaccharidosis IIIA (MPS-IIIA) may receive a diagnosis of autism spectrum disorder (ASD) due to MPS-IIIA's initial symptom similarities with ASD. This may lead to professionals receiving referrals to work with these children but unaware of how these children may respond differently to treatment. To appropriately work with…

The prediction of dangerous and/or violent behavior is particularly important to the conduct of the U.S. criminal justice system when it makes decisions about restrictions of personal freedom, such as preventive detention, forensic commitment, parole, and in some states such as Texas, when to permit an execution to proceed of an individual found…

The clinical diagnostic process for autism is complex, especially because of the high co-occurrence with other neurodevelopmental and mental health conditions (Gillberg, 2010; Lai et al., 2019). Diagnosis is more complicated in youth and adults than in younger children because life experience and development affect presentation. In particular, it…