It was deeply ingrained in the author from his undergraduate studies of psychology and courses in learning theory that people have a rational left brain and a creative right brain. Learning theory suggested that activities needed to be tailored to develop both hemispheres. Handedness in relation to abilities has been commented on from the 1800s by physicians including Karl Wernicke and Wilder Penfield. However, it was the split-brain research by Gazzaniga and Sperry in the 1960s that most significantly led to learning theories based on handedness. The theory of a lateralized brain holds that a left brain learner prefers to learn in a step-by-step sequential format, beginning with details leading to a conceptual understanding of a skill. A right brain learner prefers to learn after achieving familiarity with the general concept and then going on to specifics. It seems that while these preferences exist for individuals they do not relate to brain handedness. The effect of handedness on computer interaction has also been studied without any clear message for designers of online materials. (Contains 1 figure.)