The US Department of Justice released the final report on school violence and showed that middle school is the age when violence is high, accounting for more than 70% of all violence cases (Zweig et al., 2013). After having perpetrated, the probability that the perpetrator will commit violence again will increase significantly (Office of the Surgeon General, et al., 2001), In the later review of the perpetrators, almost 100% admitted that they were unable to control their violent behavior at that time and seemed to have an invisible impulse to urge them to commit violence, and even when they knew the harm of the violent behavior, they still committed violence without scruples (Willems et al., 2018). This indicates that among the 30% of middle school students prone to violence, the underlying age-related neuroendocrine changes are most likely to be the driving force leading to violence. In this commentary, the authors argue that school violence intervention based on neuroendocrine mechanisms may be more effective than other external factors (Rivara et al., 2016). It is of greater practical significance to use the interactive network formed between testosterone, cortisol, and dopamine at different brain center sites as the target of intervention.