This article presents the Multi-tiered Systems of Support (MTSS) as a framework Catholic schools can utilize to provide a more equitable and inclusive learning environment for all students. In an effort to advocate for the effectiveness of this framework in the Catholic school setting, the authors define the framework, its key features, and the systematic supports necessary for implementation. The article provides a succinct, yet comprehensive overview of MTSS as an umbrella that encompasses both Response to Intervention (RtI), typically considered to only address academic programming, and School-wide Positive Behavior Intervention Supports (SWPBIS), which provides a preventative and evidence-based model for addressing student behavior. This integrated framework aligns well with the notion that academics and behavior are inextricably linked, as students may express behavior challenges that are the symptom of academic difficulties or vice versa. The key features of MTSS are defined including three tiers of service delivery: Tier 1 (universal support), Tier 2 (targeted group interventions) and Tier 3 (intensive, individualized interventions). The authors also provide guidance for how Catholic schools can approach implementation of MTSS from a systematic level. [This article is a response from the field to the article in this issue, "Framework for All: Building Capacity for Service Delivery in Catholic Schools" by Drs. Michael Faggella-Luby and Christie Bonfiglio (EJ1286756).]