This year's "America's Children in Brief" continues a tradition of collaboration by agencies across the Federal Government to advance the understanding of what our Nation's children and families may need to help ensure bright, healthy futures. This year's report highlights selected special feature indicators related to COVID-19 to address the impact of this pandemic on child well-being. Indicator titles are: (1) COVID-19 Immunization; (2) Child Food Insufficiency; (3) Housing Instability; (4) Pandemic Health Care and Child Care; (5) How Schools Adapted to Pandemic Response; (6) Summer Enrichment Programs; (7) Child and Adolescent Mortality; and (8) and Substance Use and Mental Health of Adolescents. In addition to the focus on COVID-19, this brief provides a snapshot of the overall well-being of America's children through the At-a-Glance summary table displaying the most recent data for all 41 regular indicators. [For "America's Children: Key National Indicators of Well-Being, 2021," see ED615659.]