This report examines the results of the 2015 Youth Risk Behavior Survey (YRBS), developed by the Centers for Disease Control and Prevention to monitor health-risk behaviors that contribute to the leading causes of death and disability among youth and adults. The YRBS, conducted biennially at the national and state/local levels, monitors the following four risk categories: (1) unintentional injuries and violence; (2) tobacco, alcohol, and other drug use; (3) sexual behaviors; and (4) dietary behaviors and physical activity. Specifically analyzed is the relationship between representative at-risk behaviors reported by senior high students in Miami-Dade County Public Schools (M-DCPS) who participated in the YRBS. Student characteristics were found to be predictive of key risk behaviors (substance use, attempted suicide, sexual activity, and obesity) with substance use in almost every case, predicting a greater likelihood of engaging in the other key risk behaviors.