The San Diego Unified School District Striving Readers Project aims to work within the research base on adolescent literacy to conceptualize, describe and apply the elements of effective teaching and professional development with the goal of increasing the literacy achievement of struggling adolescent readers. Since the inception of the Striving Readers grant program in 2006-07, the San Diego Unified School District (SDUSD) has implemented an innovative adolescent literacy program, called Strategies for Literacy Independence across the Curriculum (SLIC), in eight middle and high schools throughout the District. An additional eight middle and high schools are participating as comparison schools. In total, 16 middle and high schools are participating in the San Diego Striving Readers evaluation study. This report summarizes the targeted and whole-school SLIC literacy programs and presents implementation and impact findings from the first four years (2006-07, 2007-08, 2008-09, 2009-10) of the 5-year evaluation study. [This report was submitted to the U.S. Department of Education, Office of Elementary and Secondary Education to fulfill requirements of the Striving Readers grant.]