The National Institutes of Health (NIH) is the largest source of funding for biomedical research in the world. Funding decisions are made largely based on the outcome of a peer review process that is intended to provide a fair, equitable, timely, and unbiased review of the quality, scientific merit, and potential impact of the research. There have…

Institutional Review Boards (IRBs) and their federal overseers protect human subjects, but this vital work is often dysfunctional despite their conscientious efforts. A cardinal, but unrecognized, explanation is that IRBs are performing a specific function -- the management of risk -- using a flawed theoretical and practical approach. At the time…

There is an ongoing tension for scientists when deciding to engage with the public about their research as many scientists view direct participation as peripheral to their role. Pressures of time, lack of support by management and a lack of communicative skills are identified by scientists as reasons for not committing to communicative…

Vulnerabilities often characterize the availability of immigrant populations of interest in social behavioral science, public health, and medical research. Refugees, asylum seekers, and undocumented immigrants present unique vulnerabilities relevant to protocol development as well as ethics review procedures and criteria. This paper describes…

On the day that Henrietta Lacks died, researcher Dr. George Gey excitedly appeared on national television. He held a vial of her cells in his hand for the entire world to see and stated, "It is possible that, from a fundamental study such as this, we will be able to learn a way by which cancer can be completely wiped out." Once separated…

Academic careers and institutional reputations are closely linked with the ability to secure funding and publish work. In today's competitive environment, it is essential for research to be clearly communicated. In our experience, many researchers need assistance with communication skills, and institutions that offer professional services in…

Purpose: Biobanks are collections of biological samples (e.g. tissue samples and body fluids) and their associated data intended for various approaches in medical research. The field of biobanking evolves rapidly as an interdisciplinary branch of research and requires educational efforts to provide skilled experts in Europe and beyond. New ways in…

Evidence-based dentistry (EBD) is an approach to oral healthcare requiring systematic assessment of relevant scientific evidence to clinical practice and patients' needs. EBD attempts to globally establish personalized dental care based upon the most recent and highest order scientific evidence. However, some times the EBD does not consider local…

Previous debate has explored whether medical education research should become more like health services research in terms of frameworks, collaborations and methodologies. Notable recent changes in health services research include an increasing emphasis on complex interventions, defined as interventions that involve more than one component. The…

Purpose: Treatment fidelity is a measure of the reliability of the administration of an intervention in a treatment study. It is an important aspect of the validity of a research study, and it has implications for the ultimate implementation of evidence-supported interventions in typical clinical settings. Method: Aphasia treatment studies…

This paper discusses the role brain disease has played in the discourse and practices of child scientists involved in the study of learning disabilities and behavioural disorders from the 1950s up to the mid-1980s, particularly in the Netherlands as part of a developing international scientific community. In the pre-ADHD era, when child sciences…

"Ethics in practice" are the ethical dilemmas that arise during the conduct of research. In this article, we describe the ethical issues we faced when conducting an exploration of the experiences of 19 potential living kidney donors, and demonstrate how reflexivity can guide the ethical decision-making throughout the research process. We…

Individuals with sickle cell disease experience a life-time of morbidity as well as a decreased lifespan. Since African Americans are disproportionately affected by the disease, sickle cell contributes to growing health disparities within this population. Thus, addressing issues related to the disease presents an increased need for health…

Since the existence of human society, medicine has always occupied a prominent place in all cultures and periods because it represents a common concern for all human beings: their health and lives. Medicine is a science and an art. The science is the evidential basis for solving clinical problems, and the art is the application of this medical…

This paper examines shifts in the knowledge production policy agenda at Japanese research universities -- a transition from discipline-based academic tradition towards interdisciplinary forms of knowledge production -- through a case study of a leading interdisciplinary research institute. We examine this transition through the case of Tohoku…