In science education, students need to work with laboratory elements that create conditions for them to learn to do science and experience the value of making meaning in this process. However, students rarely get to carry out investigations that resemble actual scientific practices. More often, they are encouraged to follow an already given knowledge structure, rather than allowed to shape it by themselves. In this study, we investigate how students' meaning-making processes develop when they work with an open inquiry with three degrees of freedom aimed at really doing science. Meaning-making in doing science involves both the typical science-content dimension and a sometimes more overlooked aesthetic dimension. Thus, to gain insight into the students' meaning-making in this, we rendered a thick description of the students' experience, including an analysis of the aesthetic dimension. We compared the processes of two student groups in year 9 and how, within their groups, they collectively made meaning of an open inquiry. The results showed how the processes took quite different turns, moving through peaks and troughs in each group. The first group began with resignation and ended up with a strong commitment towards the openness of the task. For the other group, the journey was quite the opposite. They began engaged, with a lot of ideas about a phenomenon that turned out to be impossible to create. This study shows that in this open process, the materials available and the teacher's guidance are crucial for supporting the students' meaning-making. This study therefore becomes an important contribution to a discussion about what is needed to help students make meaning in doing.