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Direct linkHeuer, Sarah E.; Neuner, Sarah M.; Hadad, Niran; O'Connell, Kristen M. S.; Williams, Robert W.; Philip, Vivek M.; Gaiteri, Chris; Kaczorowski, Catherine C. – Learning & Memory, 2020
Individual differences in cognitive decline during normal aging and Alzheimer's disease (AD) are common, but the molecular mechanisms underlying these distinct outcomes are not fully understood. We utilized a combination of genetic, molecular, and behavioral data from a mouse population designed to model human variation in cognitive outcomes to…
Descriptors: Cognitive Processes, Resilience (Psychology), Alzheimers Disease, Genetics
Gemzik, Zachary M.; Donahue, Margaret M.; Griffin, Amy L. – Learning & Memory, 2021
Spatial working memory (SWM) is the ability to encode, maintain, and retrieve spatial information over a temporal gap, and relies on a network of structures including the medial septum (MS), which provides critical input to the hippocampus. Although the role of the MS in SWM is well-established, up until recently, we have been unable to use…
Descriptors: Short Term Memory, Spatial Ability, Task Analysis, Cues
Hedman, Eli; Hartelius, Lena; Saldert, Charlotta – International Journal of Language & Communication Disorders, 2022
Background: Persons with Parkinson's disease (PD) frequently report word-finding difficulties. Many of the established tests are, however, insufficient in detecting mild cases of such symptoms. Results from earlier research have suggested that controlled oral word association tests (COWATs) with high demands on cognitive processing resources could…
Descriptors: Diseases, Language Impairments, Symptoms (Individual Disorders), Neurological Impairments
Download full textCan, Eda; Kuruoglu, Gülmira – International Journal of Psycho-Educational Sciences, 2018
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, accounts for an estimated 60 percent to 80 percent of cases. AD has two subtypes: Early-onset and Late-onset Alzheimer's disease. Both types are characterized by a decline in memory, problem-solving and other cognitive skills that affect a person's…
Descriptors: Foreign Countries, Patients, Alzheimers Disease, Age Differences
Breadmore, Helen L.; Carroll, Julia M. – Scientific Studies of Reading, 2016
Little is known about implicit morphological processing in typical and atypical readers. These studies investigate this using a probe detection task with lures sharing morphological, orthographic, or semantic overlap with the probe. Intermediate and advanced readers (reading ages = 9;1-12;9) perform more poorly when there is more linguistic…
Descriptors: Short Term Memory, Orthographic Symbols, Morphology (Languages), Semantics
Boller, Benjamin; Jennings, Janine M.; Dieudonne, Benedicte; Verny, Marc; Ergis, Anne-Marie – Brain and Cognition, 2012
Objective: This study was designed to extend the use of a memory training technique, known as the repetition-lag procedure, to Alzheimer patients. The specificity of this procedure is to target the process of recollection for improvement. Method: A group of 12 patients were trained individually for 6 h. The training procedure consisted of a series…
Descriptors: Control Groups, Intervals, Alzheimers Disease, Diseases
Nosofsky, Robert M.; Denton, Stephen E.; Zaki, Safa R.; Murphy-Knudsen, Anne F.; Unverzagt, Frederick W. – Journal of Experimental Psychology: Learning, Memory, and Cognition, 2012
Studies of incidental category learning support the hypothesis of an implicit prototype-extraction system that is distinct from explicit memory (Smith, 2008). In those studies, patients with explicit-memory impairments due to damage to the medial-temporal lobe performed normally in implicit categorization tasks (Bozoki, Grossman, & Smith, 2006;…
Descriptors: Alzheimers Disease, Classification, Patients, Short Term Memory
Gross, Rachel G.; McMillan, Corey T.; Chandrasekaran, Keerthi; Dreyfuss, Michael; Ash, Sharon; Avants, Brian; Cook, Philip; Moore, Peachie; Libon, David J.; Siderowf, Andrew; Grossman, Murray – Brain and Cognition, 2012
Prior work has related sentence processing to executive deficits in non-demented patients with Parkinson's disease (PD). We extended this investigation to patients with dementia with Lewy bodies (DLB) and PD dementia (PDD) by examining grammatical and working memory components of sentence processing in the full range of patients with Lewy body…
Descriptors: Sentences, Grammar, Dementia, Diseases
Ball, S. L.; Holland, A. J.; Watson, P. C.; Huppert, F. A. – Journal of Intellectual Disability Research, 2010
Background: Recent research has suggested a specific impairment in frontal-lobe functioning in the preclinical stages of Alzheimer's disease (AD) in people with Down's syndrome (DS), characterised by prominent changes in personality or behaviour. The aim of the current paper is to explore whether particular kinds of change (namely executive…
Descriptors: Mental Retardation, Alzheimers Disease, Diseases, Personality
Sannino, Sara; Russo, Fabio; Torromino, Giulia; Pendolino, Valentina; Calabresi, Paolo; De Leonibus, Elvira – Learning & Memory, 2012
The dorsal hippocampus is crucial for mammalian spatial memory, but its exact role in item memory is still hotly debated. Recent evidence in humans suggested that the hippocampus might be selectively involved in item short-term memory to deal with an increasing memory load. In this study, we sought to test this hypothesis. To this aim we developed…
Descriptors: Evidence, Animals, Schizophrenia, Alzheimers Disease
Grossman, Murray; Gross, Rachel G.; Moore, Peachie; Dreyfuss, Michael; McMillan, Corey T.; Cook, Philip A.; Ash, Sherry; Siderowf, Andrew – Brain and Language, 2012
While grammatical aspects of language are preserved, executive deficits are prominent in Lewy body spectrum disorder (LBSD), including Parkinson's disease (PD), Parkinson's dementia (PDD) and dementia with Lewy bodies (DLB). We examined executive control during sentence processing in LBSD by assessing temporary structural ambiguities. Using an…
Descriptors: Sentence Structure, Form Classes (Languages), Dementia, Diseases
McKee, Ann C.; Stein, Thor D.; Nowinski, Christopher J.; Stern, Robert A.; Daneshvar, Daniel H.; Alvarez, Victor E.; Lee, Hyo-Soon; Hall, Garth; Wojtowicz, Sydney M.; Baugh, Christine M.; Riley, David O.; Kubilus, Caroline A.; Cormier, Kerry A.; Jacobs, Matthew A.; Martin, Brett R.; Abraham, Carmela R.; Ikezu, Tsuneya; Reichard, Robert Ross; Wolozin, Benjamin L.; Budson, Andrew E.; Goldstein, Lee E.; Kowall, Neil W.; Cantu, Robert C. – Brain, 2013
Chronic traumatic encephalopathy is a progressive tauopathy that occurs as a consequence of repetitive mild traumatic brain injury. We analysed post-mortem brains obtained from a cohort of 85 subjects with histories of repetitive mild traumatic brain injury and found evidence of chronic traumatic encephalopathy in 68 subjects: all males, ranging…
Descriptors: Neurological Impairments, Head Injuries, Chronic Illness, Brain
Correa, Angel; Miro, Elena; Martinez, M. Pilar; Sanchez, Ana I.; Lupianez, Juan – Brain and Cognition, 2011
Cognitive deficits in fibromyalgia may be specifically related to controlled processes, such as those measured by working memory or executive function tasks. This hypothesis was tested here by measuring controlled temporal preparation (temporal orienting) during a response inhibition (go no-go) task. Temporal orienting effects (faster reaction…
Descriptors: Control Groups, Inhibition, Short Term Memory, Cognitive Processes
Peters, Frederic; Majerus, Steve; De Baerdemaeker, Julie; Salmon, Eric; Collette, Fabienne – Neuropsychologia, 2009
A decrease in verbal short-term memory (STM) capacity is consistently observed in patients with Alzheimer's disease (AD). Although this impairment has been mainly attributed to attentional deficits during encoding and maintenance, the progressive deterioration of semantic knowledge in early stages of AD may also be an important determinant of poor…
Descriptors: Control Groups, Semantics, Alzheimers Disease, Word Lists
Garcia-Osta, Ana; Alberini, Cristina M. – Learning & Memory, 2009
The amyloid precursor protein (APP) undergoes sequential cleavages to generate various polypeptides, including the amyloid [beta] (1-42) peptide (A[beta][1-42]), which is believed to play a major role in amyloid plaque formation in Alzheimer's disease (AD). Here we provide evidence that, in contrast with its pathological role when accumulated,…
Descriptors: Alzheimers Disease, Memory, Animals, Experiments
