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Direct linkHeuer, Sarah E.; Neuner, Sarah M.; Hadad, Niran; O'Connell, Kristen M. S.; Williams, Robert W.; Philip, Vivek M.; Gaiteri, Chris; Kaczorowski, Catherine C. – Learning & Memory, 2020
Individual differences in cognitive decline during normal aging and Alzheimer's disease (AD) are common, but the molecular mechanisms underlying these distinct outcomes are not fully understood. We utilized a combination of genetic, molecular, and behavioral data from a mouse population designed to model human variation in cognitive outcomes to…
Descriptors: Cognitive Processes, Resilience (Psychology), Alzheimers Disease, Genetics
Download full textCan, Eda; Kuruoglu, Gülmira – International Journal of Psycho-Educational Sciences, 2018
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, accounts for an estimated 60 percent to 80 percent of cases. AD has two subtypes: Early-onset and Late-onset Alzheimer's disease. Both types are characterized by a decline in memory, problem-solving and other cognitive skills that affect a person's…
Descriptors: Foreign Countries, Patients, Alzheimers Disease, Age Differences
Nosofsky, Robert M.; Denton, Stephen E.; Zaki, Safa R.; Murphy-Knudsen, Anne F.; Unverzagt, Frederick W. – Journal of Experimental Psychology: Learning, Memory, and Cognition, 2012
Studies of incidental category learning support the hypothesis of an implicit prototype-extraction system that is distinct from explicit memory (Smith, 2008). In those studies, patients with explicit-memory impairments due to damage to the medial-temporal lobe performed normally in implicit categorization tasks (Bozoki, Grossman, & Smith, 2006;…
Descriptors: Alzheimers Disease, Classification, Patients, Short Term Memory
Sannino, Sara; Russo, Fabio; Torromino, Giulia; Pendolino, Valentina; Calabresi, Paolo; De Leonibus, Elvira – Learning & Memory, 2012
The dorsal hippocampus is crucial for mammalian spatial memory, but its exact role in item memory is still hotly debated. Recent evidence in humans suggested that the hippocampus might be selectively involved in item short-term memory to deal with an increasing memory load. In this study, we sought to test this hypothesis. To this aim we developed…
Descriptors: Evidence, Animals, Schizophrenia, Alzheimers Disease
McKee, Ann C.; Stein, Thor D.; Nowinski, Christopher J.; Stern, Robert A.; Daneshvar, Daniel H.; Alvarez, Victor E.; Lee, Hyo-Soon; Hall, Garth; Wojtowicz, Sydney M.; Baugh, Christine M.; Riley, David O.; Kubilus, Caroline A.; Cormier, Kerry A.; Jacobs, Matthew A.; Martin, Brett R.; Abraham, Carmela R.; Ikezu, Tsuneya; Reichard, Robert Ross; Wolozin, Benjamin L.; Budson, Andrew E.; Goldstein, Lee E.; Kowall, Neil W.; Cantu, Robert C. – Brain, 2013
Chronic traumatic encephalopathy is a progressive tauopathy that occurs as a consequence of repetitive mild traumatic brain injury. We analysed post-mortem brains obtained from a cohort of 85 subjects with histories of repetitive mild traumatic brain injury and found evidence of chronic traumatic encephalopathy in 68 subjects: all males, ranging…
Descriptors: Neurological Impairments, Head Injuries, Chronic Illness, Brain
Boller, Benjamin; Jennings, Janine M.; Dieudonne, Benedicte; Verny, Marc; Ergis, Anne-Marie – Brain and Cognition, 2012
Objective: This study was designed to extend the use of a memory training technique, known as the repetition-lag procedure, to Alzheimer patients. The specificity of this procedure is to target the process of recollection for improvement. Method: A group of 12 patients were trained individually for 6 h. The training procedure consisted of a series…
Descriptors: Control Groups, Intervals, Alzheimers Disease, Diseases
Garcia-Osta, Ana; Alberini, Cristina M. – Learning & Memory, 2009
The amyloid precursor protein (APP) undergoes sequential cleavages to generate various polypeptides, including the amyloid [beta] (1-42) peptide (A[beta][1-42]), which is believed to play a major role in amyloid plaque formation in Alzheimer's disease (AD). Here we provide evidence that, in contrast with its pathological role when accumulated,…
Descriptors: Alzheimers Disease, Memory, Animals, Experiments
Borg, Celine; Leroy, Nicolas; Favre, Emilie; Laurent, Bernard; Thomas-Anterion, Catherine – Brain and Cognition, 2011
The present study examines the prediction that emotion can facilitate short-term memory. Nevertheless, emotion also recruits attention to process information, thereby disrupting short-term memory when tasks involve high attentional resources. In this way, we aimed to determine whether there is a differential influence of emotional information on…
Descriptors: Alzheimers Disease, Emotional Response, Patients, Short Term Memory
Lanfranchi, S.; Jerman, O.; Dal Pont, E.; Alberti, A.; Vianello, R. – Journal of Intellectual Disability Research, 2010
Background: The present work is aimed at analysing executive function (EF) in adolescents with Down Syndrome (DS). So far, EF has been analysed mainly in adults with DS, showing a pattern of impairment. However, less is known about children and adolescents with this syndrome. Studying adolescents with DS might help us better understand whether…
Descriptors: Adolescents, Down Syndrome, Adults, Alzheimers Disease
Possin, Katherine L.; Laluz, Victor R.; Alcantar, Oscar Z.; Miller, Bruce L.; Kramer, Joel H. – Neuropsychologia, 2011
Figure copy is the most common method of visual spatial assessment in dementia evaluations, but performance on this test may be multifactorial. We examined the neuroanatomical substrates of figure copy performance in 46 patients with Alzheimer's disease (AD) and 48 patients with the behavioral variant of Frontotemporal dementia (bvFTD). A group of…
Descriptors: Alzheimers Disease, Neurology, Short Term Memory, Brain
Ball, S. L.; Holland, A. J.; Watson, P. C.; Huppert, F. A. – Journal of Intellectual Disability Research, 2010
Background: Recent research has suggested a specific impairment in frontal-lobe functioning in the preclinical stages of Alzheimer's disease (AD) in people with Down's syndrome (DS), characterised by prominent changes in personality or behaviour. The aim of the current paper is to explore whether particular kinds of change (namely executive…
Descriptors: Mental Retardation, Alzheimers Disease, Diseases, Personality
Menard, Marie-Claude; Belleville, Sylvie – Brain and Cognition, 2009
Musical memory was tested in Alzheimer patients and in healthy older adults using long-term and short-term memory tasks. Long-term memory (LTM) was tested with a recognition procedure using unfamiliar melodies. Short-term memory (STM) was evaluated with same/different judgment tasks on short series of notes. Musical memory was compared to verbal…
Descriptors: Alzheimers Disease, Patients, Control Groups, Older Adults
Ramanathan, Vaidehi – Critical Inquiry in Language Studies, 2009
This article offers a critical discussion of notions of self as they emerge in the diaries kept by Alzheimer patients and their caregivers. It explores ways in which diary writing becomes simultaneously an agentive way by which a sense of "self" gets scripted since memory is fast slipping away, while also pointing to the fluid nature of identities…
Descriptors: Caregivers, Patients, Diaries, Alzheimers Disease
Iacono, Teresa; Torr, Jennifer; Wong, Hui Yi – Research in Developmental Disabilities: A Multidisciplinary Journal, 2010
Studies into the effects of ageing on language in adults with Down syndrome (DS) have tended to rely on measures that lack sensitivity to change because they fail to explore across linguistic domains or rely on proxy reports. The study aim was to use measures of receptive and expressive language from studies of younger individuals with DS in…
Descriptors: Mental Age, Linguistics, Alzheimers Disease, Down Syndrome
Peters, Frederic; Majerus, Steve; De Baerdemaeker, Julie; Salmon, Eric; Collette, Fabienne – Neuropsychologia, 2009
A decrease in verbal short-term memory (STM) capacity is consistently observed in patients with Alzheimer's disease (AD). Although this impairment has been mainly attributed to attentional deficits during encoding and maintenance, the progressive deterioration of semantic knowledge in early stages of AD may also be an important determinant of poor…
Descriptors: Control Groups, Semantics, Alzheimers Disease, Word Lists
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