Meta-analyzing count data can be challenging when follow-up time varies across studies. Simply pooling aggregate data over time-periods would result in biased estimates, which may erroneously inform clinical decision-making. In this study, we exploit the convolution property of the Poisson distribution to develop a likelihood for observed…

Given the grave morbidity and mortality of drug-resistant epilepsy, it is of great clinical interest to determine how often prior proven drug-resistant epilepsy is reversible without surgery and whether remission can be predicted by clinical features in children with incident drug-resistant epilepsy. We determined the likelihood of 1-, 2- and…

Aim: The long-term outcome of the Dutch pyridoxine-dependent epilepsy cohort and correlations between patient characteristics and follow-up data were retrospectively studied. Method: Fourteen patients recruited from a national reference laboratory were included (four males, 10 females, from 11 families; median age at assessment 6y; range 2y…

To provide evidence of whether seizure clustering is associated with drug resistance and increased mortality in childhood-onset epilepsy, a prospective, long-term population-based study was performed. One hundred and twenty patients who had been followed since disease onset (average age 37.0 years, SD 7.1, median 40.0, range 11-42; incident cases)…

Knowing the prognosis of epilepsy will undoubtedly influence the treatment strategy. This study aimed to define the prospects of newly diagnosed childhood epilepsy, assess the dynamics of its course, identify relevant variables and develop models to assess the individual prognosis. Four hundred and fifty-three children with newly diagnosed…

Among the findings were that female survivors, if not totally handicapped, were nearly all married; whereas surviving males who were not totally handicapped more often remained single. Journal availability: J. B. Lippincott Co., E. Washington Sq., Philadelphia, PA 19105. (Author/DLS)

Followup 8 years after reduction of antiepileptic drugs in 50 institutionalized developmentally disabled epileptic patients found recurrence of seizures in 26 patients. Predictors for a seizure-free state off medication included few documented seizures in lifetime, no gross neurological abnormalities, and persistently normal electroencephalograms.…

Five responses to Alvarez (EC 220 238) comment on discontinuation of antiepileptic drugs with mentally retarded patients. (DB)