External validity is an important parameter that needs to be considered for decision making in health research, but no widely accepted measurement tool for the assessment of external validity of randomized controlled trials (RCTs) exists. One of the most limiting factors for creating such a tool is probably the substantial heterogeneity and lack…

Background: The National Institutes of Health (NIH) announced a revised, expanded definition of 'clinical trial' in 2014 to improve trial identification and administrative compliance. Some stakeholders voiced concerns that the policy added administrative burden potentially slowing research progress. Methods: This quasi-experimental study examined…

Background: The term "intellectual disability" is increasingly used to refer to people with learning disabilities in British learning disability policy, practice and research. This change is undoubtedly a reflection of the changing international context. The inclusion of the term "intellectual disability" has been particularly…

Translational research is a new and important way of thinking about research. It is a major priority of the National Institutes of Health (NIH) in the United States. NIH has created the Clinical and Translational Science Awards to promote this priority. NIH has defined T1 and T2 phases of translational research in the medical field, in order to…

Compares scientific explanations of addiction of the 1920s and 1930s to today's. Details the history of addiction testing and research, the development of criteria for defining addiction, and both physiological and psychological definitions of addiction. Suggests that the changing status of addiction as a disease reflects different meanings…

Discusses the difficulties involved in determining the cost of clinical research in light of the changing health care market. These include confusion about terminology, lack of specificity, estimation of the cost of complications, duration of patient participation, and the assignment of personnel and infrastructure costs. (MDM)

Presents the findings of the Association of American Medical Colleges' Working Group on Preserving Medical Schools' Academic Mission in a Competitive Marketplace. Concludes that medical schools will take a variety of approaches to define and preserve their missions and that the importance of the core mission of education and research is likely to…

The research needs in the epidemiology of child sexual abuse are discussed in terms of: a definition of epidemiology, the clash between the medical and legal cultures, statistical concerns, the relationship of social class or poverty with child sexual abuse, the need for cross-cultural research, intervention studies, studies of service…