The Zones of Regulation is a widely implemented program for social-emotional regulation, including for students with autism. To date, there is very little empirical evidence to show efficacy for the Zones of Regulation. According to standards published by the American Psychological Association, National Standards Project, and National Clearinghouse of Autism Evidence and Practice, the Zones of Regulation does not meet the standards for an evidence-based practice. The authors provide suggestions in support of additional empirical study of Zones of Regulation.