This paper synthesises a large dataset on how social research methods and practices have been adapted or designed for use within pandemic conditions and a climate of crisis and uncertainty. The data were generated through two rapid evidence reviews of the methodological literature and in dialogue with social researchers in online knowledge exchange workshops. The authors apply the concepts of crisis, uncertainty and sustainability to discuss the ways in which social researchers are able to conduct research and make it valid, trustworthy and ethical in times of great challenge for research. The paper provides a big picture of the challenges and the degree of maturity and sustainability of various methodological responses. The authors conclude that some methods are at a critical juncture in their development for times of crisis and uncertainty and that these merit particular attention for those involved in capacity-building for social research.