Today, science is often regarded as a discipline that is more theoretical and less applicable. It is not clear how science works in society. The problems examined in this literature review are how the development of research on the integration of science, technology, and entrepreneurship in science learning in addition to how bibliometric networks and learning research trends integrate science, technology, and entrepreneurship. The search for articles using the Publish or Perish software was carried out on December 18, 2020. The data generated was in the form of metadata extracted from Google Scholar and Scopus through the API key, with the keyword science learning, STS, STEM, STEAM, and entrepreneurship from 2015-2020. As the result, 851 article was downloaded with their metadata which is stored in ris and tidied up in the delay. The data that has been obtained is excluded from proceedings, theses, book chapters, modules, theses, reports, and comments. Visualization with VOSviewer is carried out in three visualizations, namely network, overlay, and density. The results of the analysis show that the dominant topics are educational technology and environmental science. Research trends in 2020 are PjBL, entrepreneurship, and STEM. The less researched topics are the relationship between learning outcomes and entrepreneurship, and science technology.