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Direct linkLorna Wheaton; Dan Jackson; Sylwia Bujkiewicz – Research Synthesis Methods, 2024
During drug development, evidence can emerge to suggest a treatment is more effective in a specific patient subgroup. Whilst early trials may be conducted in biomarker-mixed populations, later trials are more likely to enroll biomarker-positive patients alone, thus leading to trials of the same treatment investigated in different populations. When…
Descriptors: Patients, Drug Therapy, Pharmacology, Outcomes of Treatment
