In the Southern States one of the most common forms of disease, especially among children, is hookworm disease. The campaign for its eradication conducted by the Rockefeller Sanitary Commission for the Eradication of Hookworm Disease is one of the most remarkable health campaigns ever waged in this country. It has shown conclusively the important part which the schools may bear in any campaign against this and other communicable diseases, especially against the soil and water pollution diseases. The aim of this bulletin is to communicate to the largest public possible the history of hookworm disease, the distribution and life cycle of the parasite causing it; its symptoms, method of cure, and, most important of all, means of absolute prevention. The measures necessary for permanent control of hookworm disease are health supervision, health instruction, and perfect sanitation. The rural school can aid in health supervision; it can supplement and drive home health instruction; and above all it can teach good health and clean living by being itself a model of sanitation for the community. Topics covered in this bulletin include: (1) Importance of the problem; (2) The hookworm and hookworm disease; (3) The State departments of education; (4) County school authorities; (5) The individual teacher; and (6) The school as a model of sanitation for the community. Individual sections contain footnotes. (Contains 8 plates.) [Best copy available has been provided.]