Classification and Regression Tree (CART) analysis is a statistical modeling approach that uses quantitative data to predict future outcomes by generating decision trees. CART analysis can be useful for educators to inform their decision-making. For example, educators can use a decision tree from a CART analysis to identify students who are most likely to benefit from additional support early--in the months and years before problems fully materialize. This guide introduces CART analysis as an approach that allows data analysts to generate actionable analytic results that can inform educators' decisions about the allocation of extra supports for students. Data analysts with intermediate statistical software programming experience can use the guide to learn how to conduct a CART analysis and support research directors in local and state education agencies and other educators in applying the results. Research directors can use the guide to learn how results of CART analyses can inform education decisions.