The Region 5 Comprehensive Center worked in partnership with the Tennessee Department of Education to develop a professional learning framework and toolkit. Although they were developed to meet the needs of education staff in Tennessee, the guidance can benefit other state education stakeholders in their efforts to ensure all professional learning experiences are: (1) high quality; (2) conducted and assessed consistently across the state; and (3) aligned with adult learning theories. The framework prioritizes a consistent approach to designing professional learning initiatives and experiences so that designers across all contexts (state, region, district, building, classroom) have access to a systematic method that can be monitored and evaluated. Results will help education stakeholders identify professional learning models that are most effective in improving education-related processes and practices, and subsequent student achievement outcomes.