The City University of New York (CUNY) is the largest urban public university system in the United States with approximately 100,000 students enrolled in associate degree programs. Similar to trends nationwide, many associate degree students come to CUNY underprepared for college-level classes and are assigned to take remedial or developmental courses in reading, writing, or mathematics. Most of these students never complete their remedial coursework, much less earn a college degree. CUNY Start, a multifaceted prematriculation program, addresses these challenges to help underprepared students make a successful transition to college. Preliminary findings from a randomized control evaluation of CUNY Start found that CUNY Start students made more progress towards proficiency, had higher rates of re-enrollment, and attempted more college credits in the second semester than the control. As part of an IES funded research project, this resource guide has been developed for college administrators, faculty, and other key stakeholders interested in exploring the CUNY Start approach to remediation. The guide describes the CUNY Start program model, the use of research and evaluation practices, and the program's incorporation into large-scale changes to remedial policy at CUNY.