Mentoring girls is a challenge. Girls will come to mentors with hard questions and great hope. Mentoring is about building trust over a long period of time. If a mentor cares about the girls and follows through with the promises that he or she makes to them, a mentor will be successful in helping them to improve their lives. This "Guide" serves as a road map for mentors. It provides ideas for helping girls as they go through school and become young adults. The first section of this "Guide" talks about being a mentor and how to prepare for mentoring activities. Later sections talk about issues that are important to girls. This "Guide" describes "life skills". These are the basic skills to help girls make good decisions as they become adults and plan for their futures. It discusses issues such as inner strength, good choices, health, and wellness. The "Guide" gives information about these topics and others, questions about each topic that mentors may want to discuss with girls, and ideas for fun learning activities that can be done in mentoring sessions or when girls are in school or with their families. (Contains 6 footnotes.) [The following people, present and past staff of the AED Center for Gender Equity, were contributors to this guide: Michele Akpo, Aissatou Balde, Jenny Barker, Judy Benjamin, Andrea Bertone, Boubacar Cisse, Melissa Crutchfield, Ahlam Ghadry, Cory Heyman, Melissa Hunter, Renu Jain, Eugene Katzin, Bridget Lombardo, Stephanie Psaki, Barbara Reese, and Alexandra Zekas.]