Preparing today's students for success and leadership in the global marketplace is the most important responsibility in education today. Providing them with guidance and opportunity at the most critical junctures along their educational journey can have a profound impact. Entrepreneurship Education is an important tool to achieving these objectives. This Guide makes the case for Entrepreneurship Education in the following ways: First, it details the extent of the innovation challenge facing America's young people, especially youth from low-income communities. It then details where and how Entrepreneurship Education can help engage children and teach critical skills. Thousands of local experiments in Entrepreneurship Education are underway around the globe. These experiences provide a host of useful insights about what works and what is needed in the field. Finally, the guide offers suggestions for what a policymaker can do to help prepare the youth to be economically productive members of society in the 21st century global economy. (Contains 1 table and 24 endnotes.) [This report was presented by the Aspen Youth Entrepreneurship Strategy Group.]