This final report contains a detailed description of six software systems designed to assist individuals with blindness and/or speech disorders in using inexpensive, off-the-shelf computers rather than expensive custom-made devices. The developed software is not written in the native machine language of any particular brand of computer, but in the universal language "C," which will run on all present and future brands of computers. The report provides user manuals describing the software for individuals with blindness, "Screen-Voice," adapted to three types of computer in use in 1984, the Apple IIe (the most popular computer in schools); IBM compatible personal computers (the most popular office computer, available in tabletop and portable versions); and the TRS-80 Model 100 (a portable computer). The report includes user manuals for "Talkhelper," a program designed to allow persons with speech disabilities to use a personal computer with a speech synthesizer as a substitute voice. Manuals are also provided for Apple IIe, IBM-compatible computers, and for the TRS-80 Model 100 portable computer. Finally, the source code of the most elaborate version of the software, that of the IBM-compatible personal computer, is reproduced in full. (CR)