This teacher's guide includes parts three and four of the four-part third year Portland Project, a three-year integrated secondary science curriculum sequence. The underlying intention of the third year is to study energy and its importance to life. Energy-related concepts considered in year one and two, and the concepts related to atomic structure and particle phenomena considered earlier in the third year are further built upon in this volume. Chapters include: monomers and how they are built; chemistry of simple carbon compounds: polymers or stringing monomers together; polymers in 3D or the shape of things to come; where the action is - the active site; polymers to polymers; genes, proteins, and mutations; energy capture; energy consumption and metabolism; and metabolism and genes. Notes to the teacher, examples of data, and problem calculations are included. (Author/SL)