This manual presents item-by-item, step-by-step procedures for the student being trained as a technician in laboratory animal care. Statements are preceeded by a box for the student to check when he has read each statement. The first 16 lessons cover: orientation; identifying, handling, and determining the sex of rodents and rabbits, cats and dogs, non-human primates, and farm animals; animal feeds and bedding; caging; special caging; and identifying tools, supplies, special clothing, and machinery. The other lessons pertain to recognizing and reporting disease in laboratory animals; inspecting the environment; cleaning, feeding, and watering animals in direct and indirect bedding cages; caring for animals in pens and special cages; restraint of the animal groups mentioned; blood collection and injection; surgery and euthanasia; vital signs; receiving and shipping rodents and rabbits; receiving large animals; and gnotobiology and breeding colonies. Notes to the instructor are interspersed among the 30 lessons. Most of them serve as suggestions for demonstration, practice, and mastery exercises. The exercises and an audio-visual component are meant to accompany the material presented in the manual. (AG)