The goal of the University of Southern California (USC) WonderKids Program is to expose students to numerous Science, Technology, Engineering, and Math (STEM) careers in an after-school setting. Elementary school students explore STEM fields with hands-on curricula and guest speakers from those fields. In partnership with the USC/Norris Comprehensive Cancer Center, a medical- and cancer-themed curriculum was developed for elementary students in the Los Angeles area. The curricula described in this article introduces first- and third-grade students to the main concepts of audiology, gastroenterology, and osteology/orthopedics fields and the way cancer can affect parts of the body that are covered in these fields. Pretests and posttests were designed to assess the impact of the educational intervention. Students demonstrated statistically significant improvements in their understanding of key objectives of all topics.