This is the teacher's guide for the "Mind Over Matter" series. This neuroscience education series, developed by the National Institute on Drug Abuse (NIDA), a component of the National Institutes of Health, is designed to encourage youngsters in grades 5-9 to learn about the biological effects of drug abuse on the body and the brain. The "Mind Over Matter" series includes eight colorful, glossy magazines, each of which is devoted to a specific drug or drug group; including stimulants, hallucinogens, inhalants, marijuana, opiates, nicotine, methamphetamine, and steroids. Each of the magazines describes the effects of specific drugs or drug types on the anatomy and physiology of the brain and the body. These educational materials further elaborate on the way in which these drug-induced changes affect both behaviors and emotions. The background information and lesson plans contained in this guide, when used in combination with the magazines in the series, will promote an understanding of the physical reality of drug use, as well as curiosity about neuroscience. The guide suggests a brain anatomy educational activity that can be used throughout the curriculum, as well as additional activities for each of the six drug topics. Teachers are encouraged to develop their own relevant lesson plans. The following are appended: (1) Resources; (2) Reading List; and (3) Reproducible Figures. (Includes 7 Figures.)