The Science of Alcohol Curriculum for American Indians uses the Medicine Circle and the "new science paradigm" to study the science of alcohol through a culturally relevant holistic approach. Intended for teachers and other educational personnel involved with American Indians, this curriculum aims to present a framework for alcohol education that integrates physical, spiritual, mental, and emotional perspectives. The rubric of science alone will not alter the impact that alcohol and alcohol abuse have had on the lives of some American Indian students. This unit of the curriculum focuses on the central nervous system (CNS) and its responses to moderate drinking and alcohol abuse. It discusses: (1) the Medicine Circle as a better model than the machine for studying the CNS; (2) the importance of culturally relevant education; (3) the structure of neurons, process of a synapse, and function of neurotransmitters; (4) effects of alcohol on neurons; (5) roles of the cerebrospinal fluid and the blood-brain barrier in brain functioning; (6) alcohol effects on the hindbrain, midbrain, and forebrain; (7) differences in alcohol reactions of high and low tolerance drinkers; (8) roles of different areas within the cerebral cortex and alcohol effects on them; (9) five common CNS disorders associated with alcohol abuse; and (10) a holistic approach to alcoholism treatment among American Indians. This training unit contains a participant booklet, 29 references, a glossary, 12 handouts and accompanying overhead transparencies, an evaluation form, and tips for a successful training session. (SV)