This curriculum resource guide on alcohol and drug prevention provides suggested activities for teachers of grades 10 through 12. Three integrated learning activities for science/biology and healthful living are presented. The science/biology goal is understanding the biology of humans. Healthful living goals include analyzing drug and alcohol use in terms of need fulfillment and personal goals, demonstrating knowledge of factors affecting the health of mother and child, understanding the relationship between life style and health status, and being aware of services for drug-related problems. Each of these activities lists goals, content summary, resources, activity, and assessment. A curriculum integration activities feedback form and blank suggested activity forms are included. A summary of North Carolina laws and punishments on driving while intoxicated or under the influence of drugs is included. Information bulletins on these topics are provided: (1) the shared responsibility of drug and alcohol education; (2) alcohol; (3) amphetamines; (4) cocaine; (5) confidentiality requirements for school personnel; (6) depressants; (7) drugs and you; (8) fetal alcohol syndrome; (9) hallucinogens; (10) inhalants; (11) legal information for school personnel regarding student alcohol or drug use; (12) Lysergic Acid Diethylamide; (13) marijuana; (14) nicotine/cigarettes; and (15) steroids. (ABL)