This brief paper presents principles of universal design of learning (UDL) and applies these principles directly to good classroom practices. UDL is an approach to learning in which curriculum designers consider the full scope of student abilities including varying abilities to see, hear, speak, move, read, write, comprehend English, attend, organize, engage, and remember. Seven principles of universal design are identified: equitable use; flexibility in use; simple and intuitive; perceptible information; tolerance for error; low physical effort; and size and space for approach and use. The paper then relates these principles to three principles of classroom practice: (1) flexibility in curriculum (teaching methods, classroom environment and assessment); (2) inclusion of every student with support provided when needed; and (3) teacher preparation and organization to optimize use of flexible curricular materials and technology, assessment of individual needs, and selection of appropriate instructional strategies. (DB)