This report examines the health and wellbeing of children in the United States' largest cities, covering every city with a population of 100,000 or more, as well as the largest cities in states without any cities of this size. Research shows that many cities are becoming more child-friendly, with better access to good education, jobs, and health care. In addition to explanations and analysis of these data, there are several articles exploring urban living and children's quality of life. The 12 chapters are: "Foreword" (Congressman David Wu); "Talking Points: Kid-Friendly Cities Report Card" (Peter H. Kostmayer); "Introduction: 2001 Kid-Friendly Cities Report Card" (Radhika Sarin); "The Real Test: Life in the Majors" (Bruce Adams); "Healthy Cities and Healthy Parks: We Can Have Both!" (Peter Harnik); "A Comeback City--For Kids" (Neal R. Peirce); "Indicators and Data: Definitions, Sources, and Rationales"; "Centerfold: Pull-out Wall Chart"; "Major Cities: Final Rankings and the Honor Roll"; "Independent Cities: Final Rankings and the Honor Roll"; "Component Cities: Final Rankings and the Honor Roll"; "Kid-Friendly Cities Benefit the Planet, Too" (Molly O'Meara Sheehan); and "Methodology and Statistical Analysis: How We Assigned Grades and Ranks" (Radhika Sarin). (SM)