This overview provides basic information on the causes of deaf-blindness and the particular challenges faced by individuals with deaf-blindness. Causes of deaf-blindness include various syndromes, multiple congenital anomalies, prematurity, congenital prenatal dysfunction, and various postnatal causes. Differences between people deaf-blind from birth and those adventitiously deaf-blind are noted. Challenges facing a person who is deaf-blind are identified, especially the learning of language and mobility skills. Challenges facing the family, teachers, and caregivers are also discussed and suggestions are given in the areas of communication, orientation and mobility, individualized education, transition, and inclusion within the family. The paper stresses that deaf-blind individuals have a unique and valuable experience of the world and can have a high quality life if they accept their condition, are provided educational experiences which help them maximize their abilities, and live in accepting families and communities. Also provided is a descriptive guide to 7 organizations that offer help to families, caregivers, and teachers and an annotated list of 10 print resources. (DB)