The National College Learning Center Association defines a learning center at institutions of higher education as interactive academic spaces which exist to reinforce and extend student learning in physical and/or virtual environments. A variety of comprehensive support services and programs are offered in these environments to enhance student academic success, retention, and completion rates by applying best practices, student learning theory, and addressing student-learning needs from multiple pedagogical perspectives. Staffed by professionals, paraprofessionals, faculty, and/or trained student educators, learning centers are designed to reinforce the holistic academic growth of students by fostering critical thinking, metacognitive development, and academic and personal success. The COVID-19 crisis affected higher education and changed operations starting in March of 2020, forcing learning center leaders to develop new ways to reach students and support their college communities. The coronavirus continued to challenge them during summer and fall semesters. This special issue shares the stories of how 48 learning centers addressed the fluid situation in order to serve their students.