The Association for the Advancement of Computing in Education (AACE) is an international, non-profit educational organization. The Association's purpose is to advance the knowledge, theory, and quality of teaching and learning at all levels with information technology. The "EdMedia + Innovate Learning" conference took place online July 6-8, 2021. These proceedings include 143 papers. Topics of the papers include: advanced technologies for learning and teaching; assessment and research; educational reform, policy, and innovation; evaluation and quality improvement advances; global networks, partnerships, and exchanges; innovative approaches to learning and learning environments; open education; technologies for socially responsive learning; virtual and distance education; and COVID-19 strategies for educators. [For the 2020 proceedings, see ED610435.]