Five plenary session presentations and summaries of 10 panel sessions held at a forum entitled "The Ecology of Substance Abuse: Toward Primary Prevention among High-Risk Youth" are provided in this document, which focuses on black youth at high risk for alcohol and drug problems. Experts describe a comprehensive ecological approach to addressing antecedent and concomitant factors related to alcohol and other drug use among black high-risk youth. Plenary session presentations are: (1) "Implications of Alcohol and Other Drug Use for Black America" (B. J. Primm); (2) "The Second Cocaine Epidemic" (D. F. Musto); (3) "Prevention Models Targeted to Black Youth at High Risk for Alcohol and Other Drug Problems" (V. L. Smith); (4) "Primary Prevention from a Public Health Perspective: The Realities of the Urban Environment" (R. Tuckson); and (5) "An Ecological Model for Prevention of Drug Use" (C. H. Edwards). Panel session summaries are: (1) "The Incidence of Alcohol and Other Drug Use"; (2) "Family, Cultural, and Environmental Risk Factors Related to Alcohol and Other Drug Use among Black Youth at High Risk"; (3) "The Interaction of Health and Nutrition"; (4) "International Dimensions of Drug Trafficking"; (5) "Pharmaceutical Industry: Friend or Foe?"; (6) "Systemic Factors Related to Alcohol and Other Drug Use"; (7) "Prevention Models for Black Youth at High Risk: Family and Religion"; (8) "Prevention Models for Black Youth at High Risk: Education and Media"; (9) "Prevention Models for Black Youth at High Risk: Industry and Government"; and (10) "Prevention Models for Black Youth at High Risk: Health Care and Civic Organizations." Three appendices provide supplemental information about the forum as well as an Office of Substance Abuse Prevention fact sheet on alcohol and other drug abuse among African Americans in the United States. (SLD)