On September 22, 2022, the National Academy of Sciences held a symposium entitled Endless Frontier 2022: Research and Higher Education Institutions for the Next 75 Years. The event was a follow up to a February 2020 NAS symposium convened to celebrate the 75th anniversary of the landmark report Science, the Endless Frontier. Building on the 2020 symposium and on lessons learned during the COVID-19 pandemic, the September 2022 symposium sought to generate tools, strategies, and actionable steps that people and institutions can implement to ensure that science and technology continue to serve the public good. The symposium was designed to progress from broad perspectives that encompass the entire science and technology enterprise to consideration of more specific issues. This proceedings summarizes the 2022 symposium. [This activity was also supported by the Kavli Foundation. Jeena M. Thomas and Steve Olson served as Rapporteurs. Policy and Global Affairs was a contributor to this report.]