This report presents state- and county-level data for the Appalachian Region. The 12 chapters focus on: (1) Population Basics; (2) Age; (3) Race and Hispanic Origin; (4) Housing Occupancy, Tenure, and Type; (5) Education, Device Ownership, and Internet Access; (6) Labor Force, Employment, and Unemployment; (7) Transportation and Commuting Patterns; (8) Income and Poverty (9) Health and Insurance Coverage; (10) Disability Status; (11) Migration; and (12) Veteran Status. Most of the data contained in this chartbook come from the 2014-2018 American Community Survey. This year's Chartbook includes two appendices. Appendix A uses selected demographic and socioeconomic measures to provide an overview comparing rural Appalachia (defined here as nonmetropolitan counties not adjacent to any metropolitan area) to rural areas outside the Appalachian Region. (It also includes a map showing the location of these rural counties.) Appendix B contains two reference maps--one of the five Appalachian subregions, and one of the five rural-urban county types. Both the subregions and county types are referenced throughout the report. [For the 2012-2016 Chartbook, see ED585953.]