This article reviews the role of faith- and community-based organizations in providing comprehensive sexuality education for adolescents in the United States. To gather information about these organizations, a broad approach was used that included a formal literature review, systematic searches through organizational Web sites, and the convening of a panel of experts who support comprehensive sexuality education in faith- and community-based organizations. This paper provides an overview of the context in which community- and faith-based organizations provide comprehensive sexuality education, the various approaches taken, and the challenges, needs, and recommendations for these programs. (Contains 1 note and 2 tables.)