Background: With a growing new materialism paradigm and research on multimodality, there is an increasing attention on the role of material objects in science teaching and learning. However, there is currently no available framework, coding scheme, or method of inquiry to specifically analyze the use of material objects in science meaning-making. Purpose: This paper presents and discusses two analytical frameworks developed to examine teachers' and students' interaction with material objects during classroom discourse. Design and methods: The first analytical framework was theoretically informed by multimodal interaction analysis (MIA), focusing on humans' situated interaction using embodied and disembodied modes located in the material world. The second framework was informed by social semiotics multimodal analysis (SSMA), focusing on material interaction as a semiotic mode with unique affordances for sign-makers to make meaning alongside other semiotic modes (e.g. speech, gesture). Sample: Both frameworks are used to analyze two vignettes of classroom discourse generated from video data to illustrate their applications, coding procedures, and interpretative potential. Results: The MIA-informed framework highlighted the dynamic and reciprocal relations between students' experiences and the transformation of materials, while the SSMA-informed framework highlighted the subtle meanings constructed with the unique affordances of the material mode. Conclusion: The affordances and limitations of the two frameworks are discussed, along with their compatibility and complementary relations. This work contributes to the emerging field of materiality in science education research and provides a foundation for future studies on the analysis of material interaction in science meaning-making.