Globalization has changed the landscape of higher education. The purpose of this study is to enhance understanding of how higher education leaders are engaging emerging questions about successful leadership, particularly when it comes to international student populations in times of crisis. Guided by the Intercultural Leadership framework, this comparative case study illuminates how university presidents from eight different countries were informed in their perceptions of international students and how they acted to support this vulnerable population. The results of this analysis highlight practical implications for higher education leaders to utilize when navigating global crises while protecting international student populations.