In 2021, EDUCAUSE is publishing a second edition of the "Horizon Report." With this inaugural issue of the Information Security edition of the "Horizon Report," EDUCAUSE has sought to expand their series of Teaching and Learning "Horizon Reports" to focus on a new area of critical importance to the future of higher education--the trends, technologies, and practices that are shaping the world of postsecondary information security. Based on a methodology that grounds the findings in the perspectives and expertise of a panel of leaders in higher education and information security, this report summarizes the panel's input on the major trends shaping higher education, including panelists' reflections on the implications of this research for the future of higher education in their particular institutional contexts. [This report was written with Michael Corn, Steve Faehl, Emily Harris, Keir Novik, Sherry Pesino, Peter Romness, and Greg Sawyer. Additional Information Security Horizon Report sponsors include: Cisco, Fischer Identity, GreyCastle Security, and Vantage Technology Consulting Group. For "2020 EDUCAUSE Horizon Report: Teaching and Learning Edition," see ED607329.]