The Collaborative Ukrainian Experiment (CUE) was a joint mission between the United States and the Ukraine (Russia) whose projects were designed to address specific questions about prior plant science microgravity experiments. The education project that grew out of this, Teachers and Students Investigating Plants in Space (TSIPS), involved teachers and students in both countries. The lessons in this guide are designed to engage students in the fascination of space biology through plant investigations. In the activities included, students grow AstroPlants through a life cycle and in the process become acquainted with germination, orientation, growth, flowering, pollination, fertilization, embryogenesis, and seed development. Activities involve making careful observations, measuring and recording data, and displaying data to make analyses. The data provide students with a better understanding of what is "normal" development in AstroPlants, and serve as the basis for comparison with data taken by the CUE investigators to help determine what developmental effects during plant reproduction are affected by microgravity. Contains 38 references including world wide web sites. (JRH)