As the new academic year begins, higher education providers (HEPs) are building on their experience of dealing with the COVID-19 pandemic--including key partnerships with public health--to mitigate possible risks of monkeypox. This briefing provides principles for the prevention and case management of monkeypox infections in UK higher education settings, with additional information on access to care and vaccination. It is for professional services staff across UK HEPs, students' unions and third-party providers, particularly those roles dealing with student and staff safety, health and wellbeing. It is especially relevant to staff working in student accommodation or social events. [This report was produced in partnership with the Universities Safety and Health Association (USHA), AMOSSHE, The Student Services Organisation, and the Student Health Association (SHA).]