By the end of March 2020, all public schools in the United States were closed to slow the spread of the novel coronavirus SARS-CoV-2. More than 50.8 million children stayed home as school systems scrambled to transition to remote or hybrid learning platforms. While the decision to close schools was difficult, the debate over when and how to reopen…

Background: To quantify the costs and consequences of managing phenylketonuria (PKU) in the UK and to estimate the potential implications to the UK's National Health Service (NHS) of keeping patients on a phenylalanine-restricted diet for life. Methods: A computer-based model was constructed depicting the management of PKU patients over the first…