It is very important for individuals with all kinds of developmental disabilities to learn skills in order to be independent at home. The purposes of the study were twofold; (1) to examine the effectiveness of caregiver-delivered home-based instruction using simultaneous prompting to children with moderate developmental disabilities on teaching chained home skills and (2) to find out whether the caregivers would be able to implement simultaneous prompting procedure correctly throughout the study. Moreover, maintenance and generalization of the acquired skills were also evaluated. Participants of the study included four children with moderate mental retardation and their caregivers. After the caregivers were trained to use the simultaneous prompting procedure at the beginning of the study and were expected to teach three different chained-home skills to their children. Results of the study revealed that caregivers were successful in using the simultaneous prompting procedure. The children acquired target skills of the study conducted with multiple exemplars. Results also showed that the children maintained them one and three weeks after the training sessions were completed, and generalized them across trainers. Results of the study were extensively discussed. (Contains 2 tables and 4 figures.)