The purpose of this study was to investigate the mediating role of mindfulness in the relationship between emotional distress tolerance and coping styles of Turkish university students. The sample of the study included 453 undergraduate students from a public university in Turkey. Participants completed the R-COPE, Distress Tolerance Scale, Cognitive and Affective Mindfulness Scale-Revised and a demographic data form. In the analysis of the data, a regression-oriented mediatory macro technique was performed, and the bootstrap procedure was employed for the mediation effect analysis. The results showed that emotional distress tolerance was associated to self-help, approach, accommodation, and self-punishment coping style with the mediating role of mindfulness. However, avoidance coping style directly predicted emotional distress tolerance without the mediation role of mindfulness. Implications for researchers and college counsellors are discussed.