Currently, the aviation business is a popular service that helps people travel conveniently, quickly, and safely. People in the airline business have become more stressed with the need to learn about inflight safety-based competence to effectively serve the broad range of passengers' needs. One reason for this is the nature of their jobs, which also affects their learning. Therefore, this research study developed an autonomous learning model to enhance inflight safety-based competence for cabin crew and then studied the effects of using an autonomous learning model to enhance inflight safety-based competence for cabin crew. This study was conducted in two parts using research and development methodology (R&D). The first phase identified problems and needs in learning about inflight safety-based competence, while the second stage examined the results of using the developed learning model. The results revealed that an autonomous learning model consisted of the model's purpose, identification and management of learning goals, knowledge development of learning strategies, the trainer's role, practical ideas, and reflection on and evaluation of the learner's learning. Furthermore, the cabin crew members had improved scores in inflight safety-based competence learning in four areas: safety policy, risk management, safety promotion, and safety assurance, compared before participating in the autonomous learning model testing. The vital learning promotion course for cabin crew dealing with the inflight safety of the passengers. The developed autonomous learning model should enhance the inflight safety-based competence of cabin crew.