The purpose of this study was to investigate the relationship between motor competence and BMI in Hispanic preschool children from low SES backgrounds. One hundred and forty-eight Hispanic low SES preschool children (male = 81, female = 67 participated in this study. All children were measured on gross and fine motor competence using the Peabody Developmental Motor Scales-2 (PDMS-2). Body Mass Index (BMI) was calculated for all participants. A Pearson correlation was used to analyze the relationship between the preschool children's BMI and PDMS-2 performance. A 2 (gender) × 3 (BMI) MANOVA was conducted to assess the gender and BMI differences on each PDMS-2 subtest. Nearly one-third of children in the study demonstrated gross and fine motor delays and slightly over one-third of the children were classified as overweight or obese. A significant negative correlation was found between BMI and visual motor integration scores. The MANOVA analysis showed that low SES Hispanic boys were significantly better in gross motor skill competence and girls were more advanced in fine motor performance. These findings will make a significant contribution to the literature in identifying relationship between motor competence and children's body weight. This study is also beneficial to practitioners and educators in designing intervention and preschool curriculum to improve children identified with motor delays and to reduce BMI through physical activity.