We explore the impacts of a Consortium of rural high schools and colleges in Tennessee engaged in partnership activities to improve high school students' college and career readiness. These 29 Consortium schools received support from the federal Investing in Innovation Fund (i3) to scale up local promising practices, including distance and online learning, college partnerships to boost dual enrollment, professional development for teachers, and college and career counseling to students. Propensity score matching was used to select 29 comparison schools from among 288 regular high schools statewide. We used a quasi-experimental, matched-control study to compare students in Consortium schools to those in matched comparison schools and found that even though most of the Consortium's components of the intervention were implemented with at least moderate fidelity, most of the impacts on student outcomes were relatively small in magnitude and were not statistically significant for all cohorts. Outcomes with positive impacts include testing college ready, participating in Advanced Placement (AP) courses, receiving a score of 3 or greater on an AP examination, enrolling in college, and persisting in college. These findings suggest that schools faced considerable challenges to reforming college and career readiness that might reflect deeper issues associated with developing and maintaining relationships and changing the cultures of schools.